SLRN-517 (anti-C-KIT)

An Anti-C-KIT mAb With A Lead Indication for Chronic Urticaria (CU)

SLRN-517 is a fully human monoclonal antibody designed to target a distinct epitope of c-KIT, a validated target that can inhibit mast cell activation in patients with chronic urticaria (CU), a market expected to grow to greater than $5.8 billion globally by 2030. Other potential indications where mast cells may play a central role include prurigo nodularis, bullous pemphigoid, and eosinophilic esophagitis.
An Anti-C-KIT mAb With A Lead Indication for Chronic Urticaria (CU)
Indications

Chronic Urticaria

Chronic urticaria (CU) is caused by MC degranulation following activation by IgE. It can be spontaneous (idiopathic) or triggered by physical stimuli (e.g., heat). Symptoms include urticaria (hives), itching, erythema, angioedema, headache, fatigue, and pain. About 2 million patients in the US suffer from urticaria at any given time.